Clinical research with nanopore sequencing technology
Nanopore DNA/RNA sequencing delivers comprehensive analysis of clinical research samples, providing rapid insight into infectious disease, microbiome analysis, cancer research, immunology, reproductive health and many other areas of biomedical research. Long reads allow accurate characterisation of structural variation (SV), repetitive regions, haplotype phasing, RNA splice variants, isoforms, fusion transcripts and epigenetic modifications.
- Real-time analysis Real-time data streaming allows immediate analysis for rapid access to results, which is critically important in pathogen identification and antimicrobial profiling.
- Ultra-long reads deliver more insight Accurately characterise repetitive regions such as HLA and structural variants associated with diseases such as cancer.
- Analyse full-length RNA transcripts Sequence complete RNA strands directly and in real-time, or analyse full-length cDNA to resolve fusion transcripts in cancer samples
- Rapid library prep & low input amounts Streamlined protocols with PCR-free options to minimise bias.
- Scalable to portable or desktop Fully scalable nanopore sequencing, without any change to the library preparation method. Experiments can be scaled using the MinION™, GridION™ or PromethION™.
How are your peers using nanopore technology?
Which approach is best for you?
DNA Sequencing
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RNA Sequencing
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Prepare
- Streamlined library prep in as little as 10 minutes
- PCR-free library prep using 400 ng DNA
- PCR option for very low input amounts
- Multiplexing options for more cost-effective analysis
Sequence
- Real-time sequencing on MinION, GridION or PromethION
Analyse
- Real-time analysis with on device or local infrastructure basecalling.
- Detect DNA modifications using open source tools
Prepare
- Streamlined library prep in as little as 2 hours
- From as low as 50 ng polyA-tailed RNA
- Multiplexing options for more cost-effective analysis
Sequence
- Real-time sequencing on MinION, GridION or PromethION
Analyse
- Real-time analysis of up to 10 million full-length reads (PCR-cDNA kit)
- On device or local infrastructure basecalling
- Detect RNA modifications using open source tools (Direct RNA kit).