Products
Services
Applications
Resources Get started
Home > Applications > Clinical research

Clinical research with nanopore sequencing technology

Real-time nanopore sequencing delivers comprehensive analysis of clinical research samples, providing rapid insights into infectious disease, cancer research, immunology, reproductive health, and many other areas of biomedical research. Long sequencing reads allow complete genomic characterisation of structural variation (SV), repetitive regions, SNVs, haplotype phasing, RNA splice variants, fusion transcripts, and epigenetic modifications.

  • Achieve results within minutes for time critical applications
  • Resolve disease-associated structural variants and repetitive regions using ultra-long sequencing reads
  • Unambiguously identify and quantify full-length RNA transcripts, detect gene fusions, and breakpoints
  • Detect base modifications as standard alongside nucleotide sequence
  • Streamline your workflow with rapid library prep and low input amounts
  • Accessible to any laboratory – scale using Flongle, MinION, GridION, or PromethION

How will you use nanopore technology?

Cancer research

Heritable disease

Infectious disease

The long, real-time reads provided by nanopore sequencing enable rapid and comprehensive analysis of variants associated with cancer, including SNVs, structural variation (SV), repeats, base modifications, and gene fusions. Whole genome, whole transcriptome, or targeted DNA or RNA approaches can be used together with sample multiplexing for cost-effective results. 

Based on current internal flow cell performance of 200 Gb (October 2018).
  • Real-time data streaming for rapid access to results
  • Resolve SV, repeats, breakpoints, phasing, and transcript isoforms using long reads
  • Eliminate amplification bias and analyse base modifications through direct DNA or RNA sequencing
  • Streamline your workflow with rapid, 10-minute library prep (DNA) and real-time analysis
  • Scale to suit your needs — 1.8 Gb Flongle; 30 Gb MinION; 150 Gb GridION; 4,800/9,600 Gb PromethION P24/P48
  • New: Fully integrated Cas9 Sequencing Kit — cost-effective, amplification-free enrichment

‘Nanopore sequencing allows same-day detection of structural variants, point mutations, and methylation profiling using a single device with negligible capital cost’

Euskirchen et al

Wigard Kloosterman: Nanopore sequencing of cancer genomes

The long, direct sequencing reads provided by nanopore technology enable complete genomic characterisation of clinical research samples, including analysis of structural variants, repeats, SNVs, phasing, base modifications and transcript isoforms. Accurately characterise compound heterozygosity using long sequencing reads. Streamlined workflows combined with real-time analysis, provide rapid access to results. 

  • Resolve SV, repeats, breakpoints, phasing, and transcript isoforms using long reads
  • Analyse data in real time for rapid access to results
  • Utilise whole genome, whole transcriptome, or targeted approaches alongside sample multiplexing for cost-effective results
  • New: Fully integrated Cas9 Sequencing Kit — cost-effective, amplification-free enrichment
  • Eliminate amplification bias and characterise base modifications through direct DNA or RNA sequencing
  • Streamline your workflow with rapid, 10-minute library prep (DNA) and real-time analysis
  • Scale to suit your needs — 1.8 Gb Flongle; 30 Gb MinION; 150 Gb GridION; 4,800/9,600 Gb PromethION P24/P48

‘Many tandem repeats in the human genome — some of which are currently uncharacterized — can be studied at once with a single sequencing run and somatic differences of unstable (expanded) TRs could be evaluated, which eventually will lead to the identification of novel disease-associated TRs and improved diagnostics’

De Roeck et al

Webinar: Detection of GBA Missense mutations and other variants using Oxford Nanopore’s MinION

Accurate, real-time identification of microorganisms and antimicrobial resistance (AMR) from clinical research samples. Oxford Nanopore offers a complete solution — from rapid, 10-minute library prep (DNA), to real-time phylogenetic and AMR analysis using the EPI2ME platform. Use metagenomic or targeted approaches (e.g. 16S rRNA). Sequence at sample source or in the lab using the portable MinION or benchtop GridION X5 or PromethION devices. 

  • Identify microbes and AMR in real-time and differentiate closely related strains using long reads
  • Streamline your workflow with rapid whole genome or targeted (e.g. 16S) approaches
  • Sequence at sample source using the portable MinION and Flongle
  • Multiplex samples for even more cost-effective results
  • Reduce bias and identify modified bases using direct, PCR-free analysis
  • Scale to suit your needs — 1.8 Gb Flongle; 30 Gb MinION; 150 Gb GridION; 4,800/9,600 Gb PromethION P24/P48
Open a chat to talk to our sales team
FAQs

FAQs

Search