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The potential role of portable, scalable DNA / RNA analysis devices in healthcare is being explored by members of the biomedical research community.

The MinION - the portable, long read, real time DNA sequencer – has been used in infectious disease surveillance, pathogen analysis, cancer research, HLA analysis, reproductive health research and many other areas of  biomedical research.

And now, the benchtop GridION is available, enabling up to five MinION Flow Cells with integrated compute, for 50-100Gb of DNA sequencing data or high volumes of RNA reads.  The high-throughput, high sample-number, on-demand PromethION is being released into early access.

MinION is for Research Use Only.  Oxford Nanopore intends to seek regulatory approval for a version of the MinION device that may be appropriate for diagnostic use.

How are your peers using the MinION for clinical research?

View these publications and movies to find out more.

Date Title Source
27/07/2017 Multiplexed nanopore sequencing of HLA-B locus in Māori and Polynesian samples BioRxiv
28/06/2017 Nanopore-based single molecule sequencing of the D4Z4 array responsible for facioscapulohumeral muscular dystrophy BioRxiv
27/06/2017 Mutational analysis in BCR-ABL1 positive leukemia by deep sequencing based on nanopore MinION technology Experimental and Molecular Pathology
27/04/2017 Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer’s disease Acta Neuropathologica
11/03/2017 Non-invasive diagnosis of cutaneous leishmaniasis by the direct boil loop-mediated isothermal amplification method and MinION™ nanopore sequencing Parasitology International
19/12/2016 Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples. Journal of Clinical Microbiology
01/12/2016 Characterization of structural variations and chromothripsis in nanopore sequencing data of human genomes Nanopore Community Meeting Event video
10/10/2016 TP53 gene mutation analysis in chronic lymphocytic leukemia by nanopore MinION sequencing Diagnostic Pathology
16/06/2016 De Novo Assembly of Human Herpes Virus Type 1 (HHV-1) Genome, Mining of Non-Canonical Structures and Detection of Novel Drug-Resistance Mutations Using Short- and Long-Read Next Generation Sequencing Technologies PLOS One
27/05/2016 MinION sequencing of malaria parasites London Calling
View all publications

What's in my pot (WIMP)

'What's in my pot' (WIMP) is a workflow that enables MinION users to identify pathogens, fungi, viruses or archaea in complex samples in real time.

Analysis begins as soon as sequence data starts being streamed (a few seconds after the experiment starts). Each read of streamed sequence data is compared against a database of microbial species, and an identification is made. At the same time, WIMP plots and updates a taxonomic tree of all microorganisms found in the sample  

There are various workflows and techniques that have been developed by members of the nanopore community to perform or enhance assembly and species identification that can be explored in the publications area and within the nanopore community

How do I get started?

You can start using MinION straight away.
For a $1,000 fee you receive a MinION and starter pack of flow cells and kits.  You also get access to a thriving online community of MinION users.

Start using MinION

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