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PromethION 24 & 48 group
Flexible, large-scale, direct DNA and RNA sequencing

Terabases of data

1 - 48 flow cells

Flexible, on-demand sequencing

High-performance compute

Analyse data in real time with 4 NVIDIA A-Series GPUs

Up to 13.3 Tb data*

* (Theoretical max output when system is run for 72 hours at 400 bases / second. Outputs may vary according to library type, run conditions, etc.)

Overview

Flexible DNA/RNA high-throughput nanopore sequencers offering the flexibility of 24 independently controllable, high-output flow cells and leveraging state-of-the-art algorithms and GPU technology, PromethION 24 (P24) provides single or multiple users with on-demand access to terabases of sequencing data. PromethION 48 (P48), our most powerful sequencing device, delivers twice the capacity and output of P24 — ideal for large- and production-scale sequencing projects.

PromethION 24 & 48 on a white background

Specifications

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Two PromethION models are available for high-throughput sequencing projects: the PromethION 24 (P24) and PromethION 48 (P48), respectively operating up to 24 and 48 flow cells at once. Both systems are deployed with the powerful PromethION A-Series tower, utilising 4 NVIDIA A-Series GPUs for real-time data handling.

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Read length

Nanopores read the length of DNA or RNA presented to them — from short to ultra-long (longest >4 Mb)

Dimensions

Compact benchtop device with compute module

Sequencing module:

  • Size: W 590 mm, H 190 mm, D 430 mm

  • Weight: 28 kg Compute module:

  • Size: W 178 mm, H 440 mm, D 470 mm

  • Weight: 25 kg

Up to 290 Gb per flow cell*

Total device output as much as:

  • Up to 6.6 Tb PromethION 24*
  • Up to 13.3 Tb PromethION 48*
Suitable applications
  • Larger genomes or projects
  • Population-scale sequencing
  • Highly multiplexed small genomes or targeted regions
  • Whole transcriptomes (direct RNA or cDNA)
On demand

Sequence what you need, when you need it

  • Run flow cells individually or together — no more sample batching
  • Each flow cell has approximately six times the sequencing capacity of a MinION Flow Cell
  • Run multiple DNA or RNA experiments at once
  • Barcode for even more samples
  • Suitable for high-throughput and service labs
Accessible
  • Small footprint — suitable for any lab
  • Easy installation with comprehensive support
High-performance compute

Sequencing and analysis in one powerful device

  • Latest generation CPU
  • 4 NVIDIA A-Series GPUs
  • 60 TB SSD data storage
  • 512 GB RAM
  • Preloaded with Ubuntu OS and MinKNOW
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Capturing genomic diversity in the human pangenome with long reads

The team used the PromethION sequencing device from Oxford Nanopore Technologies to generate ultra-long reads from each of the 47 samples. For the 29 samples sequenced entirely by the consortium...
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Scalability and accessibility for large-cohort dementia research

Using nanopore reads to support large-scale studies of dementia, the successful application of this approach in characterizing complex genomic regions associated with Alzheimer’s disease...
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Understanding the drivers of oncogenesis

Kieran O’Neill introduced the Personalized OncoGenomics (POG) Program, a 12-year research trial sequencing over 1,000 genomes and transcriptomes from participants with advanced cancer.
Read more
View all applications

Prepare

Prepare your sequencing library from DNA or RNA extracted from your sample

Sequence

Sequence your library on a flow cell and device that suits your needs

Analyse

Analyse your data from as soon as you start sequencing

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