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Nanopore sequencing offers advantages in all areas of research. Our offering includes DNA sequencing, as well as RNA and gene expression analysis and future technology for analysing proteins.

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Our goal is to enable the analysis of anything, by anyone, anywhere.

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We have developed a new generation of sensing technology that uses nanopores - nano-scale holes - embedded in high-tech electronics, to perform precise molecular analyses.

Our first products sequence DNA and RNA. We offer the only sequencing technology to combine scalability from portable to ultra-high throughput formats with real-time data delivery and the ability to elucidate accurate, rich biological data through the analysis of short to ultra-long fragments of native DNA or RNA. The sensing platform has the potential to be adapted for the analysis of other types of molecules, for example proteins.

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Use of the technology

The platform is used by scientific researchers to answer questions about the biology of people, plants, animals, pathogens and environments. It is also increasingly being used in ‘applied’ settings such as clinical diagnostics, epidemiology and food safety. It is our goal to enable users to answer a wide range of important biological questions that solve real-world challenges, whether in healthcare, epidemiology, environmental science, food and agriculture or education.

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Nanopore sequencing, the only technology that offers scientific researchers:

  • Sequence any DNA/RNA fragment length from short to ultra-long Characterise more genetic variation, versatile to broad applications
  • Direct sequencing of native DNA/RNA Generate content-rich data, including methylation
  • Data available in real time Rapid insights, and analyses that can respond to results in real time
  • Scalable from portable devices to ultra-high throughput desktop devices Sequence anything, anywhere
  • No capital investment required Accessible and cost effective
  • Simple & rapid, or automated, library prep Easy to use and versatile

"Ultra-long reads enabled assembly and phasing of the 4-Mb major histocompatibility complex (MHC) locus in its entirety"

Miten Jain, UC Santa Cruz Genomics Institute

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"Using nanopore sequencing data, we generated base level maps of the most complete human methylome ever produced"

Ariel Gershman, Johns Hopkins University

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"Long reads improve genomic assemblies by spanning repetitive regions and structural variation within the genome"

Trent Prall, University of Wisconsin

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"Long-read nanopore sequencing greatly illuminates the methylation landscape of young transposable elements in cancer"

Adam Ewing, University of Queensland

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"long reads allow easy phasing of methylation into different alleles"

Timothy Gilpatrick, Johns Hopkins University, US

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"The ability of nanopore sequencing to evaluate methylation from native DNA sequences obviated the need for bisulfite modification"

Thidathip Wongsurawat, University of Arkansas for Medical Sciences, US

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"We identified over 22,636 SVs per individual, three to five times more than those found in short-read sequencing data"

Doruk Beyter, deCODE genetics

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"Targeted long-read sequencing … allowed us to simultaneously assay repeat length, sequence content, and methylation"

Danny Miller, University of Washington, US

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"ultra-long reads…profile patterns of methylation over repetitive regions that are often difficult to detect with short-read sequencing"

Karen Miga, University of California Santa Cruz, US

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