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Benchmarking nanopore methylation analysis by comparison to publicly available bisulphite datasets


Date: 5th December 2022

Genomic DNA can be sequenced on nanopore devices without the need for fragmentation, amplification or strand synthesis, so long-range methylation information is retained in the data.

Download the poster to discover:

  • The lower bias, higher mapping rates and greater reproducibility of nanopore methylation analysis than seen with bisulphite data, as revealed by benchmarking results
  • How nanopore sequencing of unamplified genomic DNA from cancer and matched normal samples enables screening for differentially methylated regions across the whole genome

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