Benchmarking nanopore methylation analysis by comparison to publicly available bisulphite datasetsPoster
Date: 5th December 2022
Genomic DNA can be sequenced on nanopore devices without the need for fragmentation, amplification or strand synthesis, so long-range methylation information is retained in the data.
Download the poster to discover:
- The lower bias, higher mapping rates and greater reproducibility of nanopore methylation analysis than seen with bisulphite data, as revealed by benchmarking results
- How nanopore sequencing of unamplified genomic DNA from cancer and matched normal samples enables screening for differentially methylated regions across the whole genome