Population genomics

Comprehensive genomic characterisation

• Long and ultra-long reads (up to 4 Mb) allow complete resolution of complex genomic aberrations
• Accurately identify and phase single nucleotide variants, structural variants, and base modifications in a single sequencing assay
• Generate and compare highly accurate genomes, and correct existing reference genomes

Limited genomic characterisation

Short sequencing reads do not typically span important classes of genomic aberrations such as large structural variants and repeat regions, instead relying on indirect inference and/or complex computational analyses for their detection. The requirement of traditional sequencing technologies for amplification can also introduce sequence bias and removes base modifications. As a result, only a fraction of the genomic variation present in a sample may be identified.

Flexible and on demand

• Scalable, affordable devices to suit all genome and project sizes
• Generate terabases of data with PromethION — use up to 48 high-capacity flow cells simultaneously or independently to match your sample availability and lab requirements
• Sequence smaller genomes at high throughput or perform low-pass sequencing of larger genomes with GridION
• Discover the advantages of nanopore sequencing and undertake pilot projects with MinION, at just $1,000, including flow cells and sequencing reagents
• Perform sample QC prior to large-scale studies using Flongle, with flow cells at $90 each

Limited flexibility

Traditional high-throughput benchtop sequencing devices require significant infrastructure requirements and expense — confining their use to well-resourced, centralised locations. Sample batching is often required for optimal efficiency, potentially leading to long turnaround times.

Streamlined workflows

• Prepare DNA samples for sequencing in as little as 10 minutes, including multiplexing
• Easy-to-automate sample preparation kits and protocols suitable for large-scale population genomics projects
• Low DNA input requirements
• Run multiple analyses — whole genome, targeted, and full-length RNA sequencing — on a single device and at the same time, with modular PromethION and GridION

Laborious workflows

Typically, lengthy sample preparation requirements and long sequencing run times, reducing workflow efficiency and increasing turnaround times.

Real-time data streaming

• Analyse data as it is generated for immediate insights
• Gain enhanced coverage of specific genomic regions with real-time targeted sequencing using adaptive sampling
• Stop sequencing when sufficient data generated — wash and reuse flow cell

Fixed run time with bulk data delivery

Increased time-to-result and inability to identify workflow errors until it’s too late, plus additional practical complexities of handling large volumes of bulk sequence data.