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Oxford Nanopore broadens its Q20+ Early Access Programme and releases new nanopore, R10.4, into this early access programme

Thu 23rd September 2021

The Oxford Nanopore “Q20+” kit is now available to any Oxford Nanopore user who registers their interest. As part of this Early Access programme, Oxford Nanopore will make available its latest flow cell chemistry, “R10.4” for first user trials.

First announced at the London Calling conference in May 2021, the Q20+ chemistry enables users to generate raw read sequencing data to an accuracy greater than Q20 (99%+) and additionally, generate Duplex data — with accuracies of 99.8% and above demonstrated.

Q20+ has been trialled by a number of early access users over the summer. Users have successfully generated data and shared results, and Oxford Nanopore has now broadened the Early Access Programme, which is now open to anyone registering their interest on the Q20+ Early Access page.

Early Access users of Q20+ will now have the opportunity to use the latest flow cell chemistry, R10.4.  It is expected that this flow cell, containing a newly iterated design of nanopore, will be an upgrade to R10.3. It is anticipated that R10.4 flow cells will replace R10.3 in the Nanopore Store over the coming weeks.  In internal trials, the R10.4 nanopore has shown a better signal profile with extended homopolymer accuracy and improved performance in consensus and indel calling when compared to R10.3.

Users trialling the new R10.4 flow cell will be able to verify its performance and share data across the community.  Further technical information on the new chemistry is expected to be released during the coming weeks.

This latest update is part of a long-term, continual process of iterative performance improvements that are designed to improve user experience and enable broader applications on the platform.

How to access Q20+ kits and R10.4 flow cells

Users who register can gain access to the Q20+ store and community.  They will then be able to trial the Q20+ chemistry on both R9 and R10 flow cells.

This also allows users to remain up to date with the latest relevant developments, such as MinKNOW updates facilitating the Q20+ chemistry and basecalling updates in Guppy. As new versions of kits or flow cells become available, users will be sent a trial pack to assess and provide their feedback.

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