Investigating epigenomic alterations in cancer with nanopore sequencing

Alberto Magi will introduce the first study that uses high-coverage whole-genome nanopore sequencing to study epigenomic alterations in cancer. Magi and colleagues applied nanopore sequencing to the analyses of clonal epigenomic evolution and mechanisms of drug resistance in research samples of acute myeloid leukemias at diagnosis and relapse after chemotherapy.

Magi will discuss the capability of nanopore sequencing data to:

• Generate high-resolution maps of CpG methylation state as compared to classical bisulfite sequencing methods.
• Exploit methylation data for finding differentially methylated regions (DMRs).
• Annotate and evaluate the functional impact of DMRs.

Meet the speaker

Alberto Magi is an Associate Professor of Bioengineering in the Department of Information Engineering at the University of Florence. He is principal investigator of the Investigator Grant of the Associazione Italiana per la Ricerca sul Cancro (AIRC) entitled "Third Generation Cancer Genomics." His research interests focus on computational genomics, particularly on the development of tools to analyse the data generated by nanopore sequencing platforms to study cancer genetic and epigenetic alterations.