Telomere-to-telomere phased genome assembly using error-corrected Simplex nanopore reads
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For telomere-to-telomere studies, many researchers use at least two long-read sequencing technologies. This approach results in increased costs and a requirement for a higher starting amount of DNA. Here the authors have developed the HERRO model which error corrects nanopore simplex ultra-long reads, increasing accuracy up to 100-fold. This data can then be used to achieve highly contiguous assemblies comparable to a combined sequencing approach.
