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New detection of SARS-CoV-2 in two cats height months after COVID-19 outbreak appearance in France

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Although there are several reports in the literature of SARS-CoV-2 infection in cats, few SARS-CoV-2 sequences from infected cats have been published. In this report, SARS-CoV-2 infection was evaluated in two cats by clinical observation, molecular biology (qPCR and NGS), and serology (Microsphere immunoassay and seroneutralization).

Following the observation of symptomatic SARS-CoV-2-infection in two cats, infection status was confirmed by RT-qPCR and, in one cat, serological analysis for antibodies against N-protein and S-protein, as well as neutralizing antibodies. Comparative analysis of five SARS-CoV-2 sequence-fragments obtained from one of the cats showed that this infection was not with one of the three recently emerged variants of SARS-CoV-2.

This study provides additional information on the clinical, molecular, and serological aspects of SARS-CoV-2 infection in cats.

Authors: Matthieu Fritz, Nicolas Nesi, Solene Denolly, Bertrand Boson, Vincent Legros, Serge G. Rosolen, Alexandra Briend-Marchal, Meriadeg Ar Gouil, Eric M. Leroy
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  • Published on: March 24 2021
  • Source: BioRxiv

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