NCM 2022: Nanopore modified base update

The nanopore sequencing platform generates a unique, information-rich output capable of detecting various base analogues. The release of the Remora modified base detection algorithm, separating the basecalling and modified base detection tasks, greatly simplified this process while simultaneously improving methylation detection accuracy. This talk will explore the latest developments in the Remora including 5-hydroxymethylation detection and all-context modified base detection training and current performance. Nanopore sequencing is quickly becoming the gold standard platform for methylation, and we aim to expand the catalogue of standard models available and enable the expansion of this catalogue more easily via the incredible nanopore community.