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Nanopore sequencing reveals structural variants in early-stage mycosis fungoides


Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma with diverse disease progression, a lack of recurrent point mutations and a high prevalence of copy number variants (CNVs). As such, an outstanding importance of CNVs and the causal structural variants (SV) on tumorigenesis is proposed. Currently, further understanding of this disease is hindered by a lack of sequenced early-stage MF cases due to low tumour purity.

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