Products & Services
Applications

Applications

Nanopore sequencing offers advantages in all areas of research. Our offering includes DNA sequencing, as well as RNA and gene expression analysis and future technology for analysing proteins.

Learn about applications
View all Applications
Resources
News Explore
Contact Get started
Resource Centre
Back

Long-Read Sequencing Revealed an Extensive Transcript Complexity in Herpesviruses

Publication

Date: 17th July 2018 | Source: Frontiers in Genetics

Authors: Dóra Tombácz, Zsolt Balázs, Zsolt Csabai, Michael Snyder, Zsolt Boldogkői.

Long-read sequencing (LRS) techniques are very recent advancements, but they have already been used for transcriptome research in all of the three subfamilies of herpesviruses. These techniques have multiplied the number of known transcripts in each of the examined viruses. Meanwhile, they have revealed a so far hidden complexity of the herpesvirus transcriptome with the discovery of a large number of novel RNA molecules, including coding and non-coding RNAs, as well as transcript isoforms, and polycistronic RNAs. Additionally, LRS techniques have uncovered an intricate meshwork of transcriptional overlaps between adjacent and distally located genes. Here, we review the contribution of LRS to herpesvirus transcriptomics and present the complexity revealed by this technology, while also discussing the functional significance of this phenomenon.

Read the full text

Recommended for you

Open a chat to talk to our sales team
FAQs

FAQs

Search