Genomic hotspots in the DENV-2 serotype (E, NS4B, and NS5 genes) are associated with dengue disease severity in the endemic region of India

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Dengue fever is a global public health concern, with an estimated 390 million infections each year. Using Oxford Nanopore sequencing, researchers analysed over 3,200 DENV-2 viral genomes from India’s 2023 dengue outbreak, identifying 1.6 million single nucleotide variants (SNVs). With whole-genome analysis, they found clusters of SNVs associated with disease severity — an insight that could guide targeted interventions and inform outbreak response in the future.

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Authors: Varsha Ravi, Kriti Khare, Ramakant Mohite, Pallavi Mishra, Sayanti Halder, Richa Shukla, Chinky Shiu Chen Liu, Aanchal Yadav, Jyoti Soni, Kanika, Komal Chaudhary, Neha, Bansidhar Tarai, Sandeep Budhiraja, Pooja Khosla, Tavpritesh Sethi, Md Imran, Rajesh Pandey
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  • Published on: April 29 2025
  • Source: PLOS Neglected Tropical Diseases