Genomic characterization of persistent enterococcal bacteremia in the VENOUS cohort
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•Enterococci are a leading cause of hospitalacquired bloodstream infections and a pathogen of increasing importance.
•The genomes of enterococci are highly dynamic, facilitating adaptation under environmental, antibiotic, and immune selective pressures.
•Adaptive evolution of these pathogens results in infections that persistent even after the initiation of antimicrobial therapy. •Previous studies have shown gain of, or changes in, genes associated with specific functional groups, such as in genes involved in carbohydrate or alternative nutrient utilization in enterococci in vivo.
•There has been little research done on the genomic and clinical dynamics of enterococcal bloodstream infection