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Exploring the potential of chemo-enzymatic technology for improved detection of epigenetic modifications with nanopore sequencing


We developed enzymatic technology that adds bulky chemical moieties to modifications, enhancing detection sensitivity during nanopore sequencing and allowing genome-wide detection with a small train-set. Specifically, we have shown that attachment of UDP-Glucose-Azide to 5hmC moieties significantly improves nanopore sensing ability, providing a promising avenue for characterizing other epigenetic modifications.

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