Main menu

Emergence and evolution of a prevalent new SARS-CoV-2 variant in the United States


Genomic surveillance can lead to early identification of novel viral variants and inform pandemic response. Using this approach, we identified a new variant of the SARS-CoV-2 virus that emerged in the United States (U.S.). The earliest sequenced genomes of this variant, referred to as 20C-US, can be traced to Texas in late May of 2020. This variant circulated in the U.S. uncharacterized for months and rose to recent prevalence during the third pandemic wave.

It initially acquired five novel, relatively unique non-synonymous mutations. 20C-US is continuing to acquire multiple new mutations, including three independently occurring spike protein mutations. Monitoring the ongoing evolution of 20C-US, as well as other novel emerging variants, will be essential for understanding SARS-CoV-2 host adaptation and predicting pandemic outcomes.

Authors: Adrian A. Pater, Michael S. Bosmeny, Christopher L. Barkau, Katy N. Ovington, Ramadevi Chilamkurthy, Mansi Parasrampuria, Seth B. Eddington, Abadat O. Yinusa, Adam A. White, Paige E. Metz, Rourke J. Sylvain, Madison M. Hebert, Scott W. Benzinger, Koushik Sinha, Keith T. Gagnon

Getting started

Buy a MinION starter pack Nanopore store Sequencing service providers Channel partners

Quick links

Intellectual property Cookie policy Corporate reporting Privacy policy Terms & conditions Accessibility

About Oxford Nanopore

Contact us News Media resources & contacts Investor centre Careers BSI 27001 accreditationBSI 90001 accreditationBSI mark of trust
English flag