Direct RNA nanopore sequencing reveals rapid RNA modification changes following glucose stimulation of human pancreatic beta-cell lines
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- Published on: June 12 2025
- Source: bioRxiv
Mulroney, Taylor, and Lee et al. used Oxford Nanopore direct RNA sequencing to investigate how glucose levels affect RNA modifications in human pancreatic beta cells, uncovering thousands of glucose-responsive changes. The study reveals that these modifications, especially m⁶A, are enriched in type 2 diabetes–related genes and act independently of gene expression, offering new insights into RNA-based regulation in diabetes.
Sample type: human pancreatic beta cell lines
