Cas9-directed long-read sequencing to increase the resolution of optical genome mapping to single basepair level
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Leukemias are clinically and genetically heterogeneous. The type of genetic aberration is important for progression prognosis and choice of treatment. Karyotyping, SNP-Array and FISH are the standard-of-care (SOC) methods in leukemia diagnostics. Optical genome mapping (OGM) is a technique that can detect different types of structural aberrations and is able to replace the SOC methods in one technique.