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Devin Drown

Alaskan Soil Resistome: Widespread Antibiotic Resistance in a Permafrost Thaw Gradient

Abstract

Natural antibiotic resistance has been found in ancient microbes in permafrost that predates the discovery of antibiotics. As climate change thaws the permafrost, antibiotic resistant microbes may have a significant negative impact on the health of Alaskans. Identifying specific antibiotic resistant microbes is essential for quick and appropriate treatment. Using culture-based methods, we found widespread antibiotic resistance in local boreal forest soils effected by thawing permafrost. Using novel metagenomic analysis of long-read, nanopore DNA sequence data, we identify individual resistance genes. Importantly, these methods allow us to better understand the environmental reservoir of antibiotic resistance in Alaska.
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