In this knowledge exchange, we will explore the multifaceted applications of multiomic nanopore sequencing in disease research, with best-practice introductions to nanopore sequencing workflows and real-world case studies. Join us at 4pm UK time (11am EST).

First, Sayonika Mohanta (Market Segment Manager — Methylation) will introduce how multiomic nanopore sequencing data — spanning whole-genome sequencing, bulk and single-cell transcriptomics, methylation analysis, and 3D chromatin analysis — provides deeper insights into mechanisms of disease.

Next, Scott Hickey (Director - Genomic Applications) will present the use of whole-genome and single-cell transcriptome sequencing to study the adaptive immune response. He will share how, in a collaboration with Benhur Lee Laboratory (Icahn School of Medicine at Mount Sinai, USA), full-length immunoglobulin transcript sequences paired with a haplotype-resolved germline assembly from the same research sample provided a comprehensive view of personalised immune responses.

Finally, Art Rand (Research Scientist, Machine Learning) will share how multiomic nanopore sequencing techniques were used to study methylation and CTCF-dependent control of 3D chromatin structure in both normal and malignant haematopoiesis. This research, from Aaron Viny (Columbia University Irving Medical Center, USA), explores how chromatin architecture and cohesin mutations impact gene regulation and contribute to transcriptional dysregulation and transformation in blood cells.

In this webinar, participants will learn:

• How multiomic nanopore sequencing approaches — integrating genomics, bulk and single-cell transcriptomics, chromatin conformation capture, and genomic variant and methylation data — can enhance research into mechanisms of disease

• How whole-genome and single-cell transcriptome nanopore sequencing can be leveraged for novel antibody discovery and understanding immune response dynamics

• How multiomic nanopore sequencing enables exploration of the relationship between 3D chromatin structure, cohesin complexes, and gene regulation in normal and malignant hematopoiesis