RNA Leaders 2025
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RNA Leaders is a must-attend event focused on RNA medicines such as RNAi, antisense, non-linear RNAs, RNA editing and targeting RNA, as well as manufacturing development of mRNA therapies and vaccine. The event features 4 simultaneous tracks covering in-depth development strategies, trends and technologies across the entire long and small RNA spectrum and areas of focus.
RNA Leaders Europe Tracks & Highlights:
- Analytics & Discovery 2.Delivery
- Next-Gen RNA
- CMC & Scaling
- Delivery & Process Development
- Oligo-based Therapeutics
- mRNA therapeutics & vaccines clinical advancements
- Workshops and forums
Oxford Nanopore will be located at booth 7, and will host a seminar on Wednesday 5 March 2025.
Date: Wednesday 5 March, 2025
Time: 12.05 pm - 12:30 pm CET
Location: Delivery & Discovery Stream, RNA Leaders Europe
Title: Plasmid DNA and Direct RNA Sequencing for mRNA QC
Description:
• Current mRNA characterization uses testing methods which require large capital investment, a considerable workforce, can be slow and cumbersome and do not always analyse the native molecule
• Explore rapid comprehensive Oxford Nanopore Technologies based CQA testing pipeline extending from the plasmid identity to the drug substance (mRNA) and drug product (mRNA) can complement state-of-the-art techniques by providing an orthogonal analysis while addressing current bottlenecks
• Direct RNA chemistry enables sequencing RNA transcripts without the requirement of first converting to DNA, nor the need for PCR amplification
• Specific basecallers for transcripts containing RNA modifications, including N1-methyl-pseudouridine, which is relevant to mRNA production, and poly(A) tail length estimation
Seminar Speaker
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Libby Snell, Director, RNA and cDNA Sample Technology, Oxford Nanopore Technologies
