Press release: Oxford Nanopore announces further collaborations for nanopore sensing technology

January 8, 2013, Oxford, UK. Oxford Nanopore Technologies, the leading developer of nanopore sensing technology for the analysis of DNA, RNA, proteins and other single molecules, announces that it has completed a series of agreements with leading academic research institutions including University of Illinois at Urbana-Champaign, Brown University, Stanford University, Boston University, University of Cambridge and University of Southampton.

Oxford Nanopore has an intellectual property portfolio of more than 300 issued patents and patent applications in over 80 patent families. The Company is currently pursuing techniques for nanopore-based analysis using biological and solid-state nanopores, as well as hybrid versions of these, and also including a wide variety of adaptations and modifications. The expanded IP portfolio now covers a broad range of technologies, including:

• DNA base identification using a biological nanopore
• Characterisation of individual polymer molecules based on monomer-interface interactions
• Addition of adapters to nanopores for sensing
• Genetically modified nanopores for sensing
• Combining nanopores and enzymes for sensing
• Use of molecular motors in combination with nanopores
• Localising polymerases to a surface, including pore-bound localisation
• Use of solid state nanopores for detecting labelled ssDNA and dsDNA
• Use of solid state devices to control movement of polymers
• Detection and positional measurement of probes on a DNA strand as the strand passes through a nanoscale detector
• Methods of fabricating solid-state nanopores including multi-layered devices
• The use of functionalised solid-state nanopores for molecular characterisation, including graphene, tunnelling currents and nanotubes
• Time-based multiplexed nanopore measurements on a single chip, including the incorporation of 96 well plate
• Use of voltage to control DNA under feedback
• Measurement of DNA interacting with a limited volume, such as a polymerase on a surface
• Planar lipid bilayer array chip for parallel sensing from multiple channels
• Sequencing by means of detection of products of enzymatic action on DNA/RNA using a nanopore
• The use of multiple 'nodes' to analyse a single sample in a federated/clustered manner to reduce the time to result, and improve operating efficiencies
• Methods and algorithms for analysing nanopore signals

"Oxford Nanopore has invested substantial resources into building its expertise, know-how and intellectual property portfolio that will support our leadership in nanopore sensing technologies. The collaborations announced today add to our existing positions in core areas spanning current and future generations of nanopore technology," said Dr Gordon Sanghera, CEO of Oxford Nanopore. "We are pleased to support further innovation in the laboratories of our collaborators, to complement the pioneering work being performed by our own interdisciplinary R&D staff. "

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Oxford Nanopore Technologies
For more information about Oxford Nanopore's technology and intellectual property portfolio please visit https://www.nanoporetech.com/our-company/intellectual-property

Oxford Nanopore Technologies Ltd is developing a novel technology for direct, electronic detection and analysis of single molecules using nanopores. The modular, scalable GridION system and miniaturised MinION device are designed to offer substantial benefits in a variety of applications.

The Company is developing a range of applications for its nanopore sensing technology, with use in scientific research, clinical and industrial applications and all compatible with the GridION and MinION systems. These include: DNA sequencing which combines a nanopore with a processive enzyme for the analysis of DNA, and Protein Analysis techniques that combine target proteins, aptamers and nanopores for direct, electronic analyses of those target proteins.

Oxford Nanopore has collaborations and exclusive licensing deals with leading institutions including the University of Oxford, Harvard and UCSC. The Company has funding programmes in these laboratories to support the science of nanopore sensing. Oxford Nanopore has licensed or owns more than 300 issued patents and patent applications in more than 80 patent families that relate to many aspects of nanopore sensing from protein nanopores to solid state nanopores and for the analysis of DNA, proteins and other molecules. This includes the use of functionalised solid-state nanopores for molecular characterisation, methods of fabricating solid-state nanopores and modifications of solid-state nanopores to adjust sensitivity or other parameters.