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Targeted nanopore sequencing using hybridisation probes reveals immune escape polymorphisms in malaria vaccine candidates


MALARIA

  • Caused by eukaryotic parasites (Plasmodium spp.)
  • Transmitted by anopheline mosquitoes
  • Major cause, and effect of poverty worldwide
  • Increasing resistance to interventions

MALARIA VACCINE DEVELOPMENT

  • Only one candidate has passed Phase 2 trials (RTS,S based on Circumsporozoite Protein, CSP)
  • Partial and short-lived efficacy in infants after 4 doses
  • Evidence of immune escape

PROBLEM:

  • Diverse antigens
  • Immune escape
  • Which polymorphisms?

SOLUTION:

  • Discover polymorphisms associated with immune escape
  • Targeted sequencing using Nanopore
  • Samples from longitudinal cohorts from Papua New Guinea

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