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Hans Jansen

The beauty and the beast

About Hans Jansen

Hans Jansen is CTO at Future Genomics Technologies based in Leiden in the Netherlands. A molecular biologist with broad experience, his focus has been on the use of next generation sequencing and bioinformatics for genome assembly and transcriptome analysis. As CTO he is responsible for the translation of academic knowledge and novel technologies into usable applications, providing early and easy access to these applications.

Leading the implementation of the MinION at ZF screens, he has been a member of the MARC consortium since it started in 2014. This group was formed to provide independent evaluation of the platform, pool data and analysis techniques, and exchange ideas for how to improve the sequencing protocol or bioinformatic processing.

Having used the MinION, GridION X5, and PromethION in their various genome projects, Hans has a wealth of experience in using the growing number of tools available for nanopore reads, and all from a biologists view point.

Abstract

The Netherlands and tulips have for a long time been tightly linked and tulip agriculture is flourishing in our country. But tulip breeding isn’t without problems. Tulip breeding takes a long time and going from tulip seeds to a commercial product takes around 25 years. Pesticide use in tulip agriculture is relatively high so identifying traits that confer resistance to pests is an important issue. Having a tulip genome sequence will assist breeders in a more targeted breeding strategy. The genome of most tulip species is between 20 -35 Gbp which has prevented the sequence and assembly of this genome up until now. Sequencing and assembly of large genomes in general is a real challenge, but with the arrival of the alpha/beta PromethION, producing the sequence data for such a project has become easier. The next challenge is to order all this sequence data in a genome sequence. The long-read scaffolder/assembler Tulip was developed to do this in a reasonable amount of time. I will be discussing the sequencing and assembly of Tulipa gesneriana ‘Orange Sherpa’ using Tulipa-julia, the successor of Tulip.

Hans Jansen

Hans Jansen

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