Epigenetics

This guide introduces Oxford Nanopore sequencing solutions for biopharma that can be applied from biomarker discovery through to final product quality control (QC) testing.

This guide provides an introduction to performing targeted nanopore sequencing.

This guide introduces how to sequence human genomes with Oxford Nanopore, from the construction of new, highly complete reference assemblies to the comprehensive identification of variants.

This guide provides an introduction to the direct sequencing of DNA methylation in human genomes.

This end-to-end workflow provides a scalable method to identify previously hidden and potentially pathogenic variants.

Discover the Hereditary Cancer Panel workflow and streamline your precision oncology research.

This end-to-end workflow provides a simple method to characterise RNA modifications from a human blood research sample using direct RNA sequencing.

This end-to-end workflow overview provides a simple solution for detecting a wide range of tumour-specific variation in a single sequencing assay.

This end-to-end workflow introduces how to perform rapid whole-genome human variant and methylation calling from a blood research sample using high-output DNA sequencing on PromethION 24.

In this application note, we present the design and performance of the Oxford Nanopore Hereditary Cancer Panel targeting 258 key genes implicated in cancer predisposition.

In this flyer, find out how Oxford Nanopore provides gold-standard methylation sequencing and comprehensive variant calling in a single run — without chemical conversion.

Find out how multiomic nanopore sequencing can accelerate your disease research using a single platform.

Discover how the Oxford Nanopore rapid whole-genome sequencing workflow is delivering fast, actionable results in 24 hours from sample collection.

Discover EPI2ME and how it provides data analysis for all levels of expertise

Homologous recombination deficiency (HRD) affects breast, ovarian, pancreas and prostate cancers. Patients with HRD tumours can respond to poly ADP-ribose polymerase (PARP) inhibitors and platinum-based therapies. HRD results in a variety of single base, insertion and deletion, and large structural

Timely and comprehensive molecular classification is essential for therapeutic decision-making in pediatric oncology, yet current diagnostic workflows rely on multi-step, time- and resource-intensive testing. We present a standardized Oxford Nanopore Technologies whole-genome sequencing approach usi

AbstractDiscover adaptive sampling: a simple, on-device enrichment method that requires no additional wet-lab prep and offers real-time data analysis for faster access to results.

What if targeted sequencing took place during sequencing itself, without the need for special library prep, PCR, or probes? In this demo, discover Adaptive Sampling: a unique, real-time targeted enrichment/depletion method that achieves just that.

In this case study, discover the benefits of adaptive sampling and how it has been applied to cancer research.

This protocol describes how to carry out preparation and sequencing of a human cfDNA sample using the Ligation Sequencing Kit V14 (SQK-LSK114). Typically, we obtain ~50 Gb of aligned data (15x coverage) for human cfDNA samples processed with this protocol.

This protocol describes how to carry out preparation and sequencing of 12 human cell-free DNA (cfDNA) samples using the Native Barcoding Kit 24 V14 (SQK-NBD114.24). Typically, we obtain ~3 Gb of aligned data (1x coverage) for each of the 12 human cfDNA samples processed with this protocol.

For Research Use Only. Document version: RRMS_9180_v114_revM_19Sep2025

For Research Use Only.

Authors: Min Seon Park, Erin Crotty, Trent Prall, Miranda PG Zalusky, Jeff Stevens, Vera Paulson, Rebecca Ronsley, Kristyn Galbraith, Joy Goffena, Sophie HR Storz, Zachery B. Anderson, Angela L. Miller, Matthew Snyder, Bonnie Cole, Sarah Leary, Tina Lockwood, Danny Miller

Authors: Xinrong Xu, Liangliang Qiu, Minghui Zeng, Qifang He, Xiaodan Lin, Yuhua Lin, Xinyue Chen, Fuze Zheng, Zeling Zheng, Shuhui Zhu, Yali Hong, Feng Lin, Ning Wang, Minting Lin, Zhiqiang Wang

Presented at AACR 2026, this recording demonstrates how rapid molecular insights can be leveraged to inform clinical decision-making and advance time-critical cancer care.

Watch this webinar to learn more about leveraging Oxford Nanopore gold standard methylation sequencing in your research.

Authors: Naohiro Makise, Jason Lin, Yuki Nakamura, Hajime Kageyama, Ryuta Kojima, Hideyuki Kinoshita, Hiroto Kamoda, Yoko Hagiwara, Mariko Oikawa, Takahiro Sugiyama, Akinobu Araki, Tsukasa Yonemoto, Masahito Kawazu, Makiko Itami