Detection and assembly of extrachromosomal DNA (ecDNA) in tumours
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Perform rapid sequencing and methylation analysis of extrachromosomal DNA (ecDNA) using nanopore technology, to assess cancer heterogeneity, oncogene overexpression, and environmental adaptation potential.
Download the poster to discover:
- The structure of ecDNA
- A bioinformatics workflow for detecting and assembling ecDNAs, using whole-genome nanopore sequencing data
- How real-time data streaming with nanopore sequencing technology enables the characterisation of ecDNA within the first few hours of sequencing
- A multiplexed approach for analysing several tumour samples in one MinION sequencing run, followed by ecDNA assembly and methylation analysis