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Software release 0.4.0 for Dorado

Version: 0.4.0

Release date: 10/10/2023

  • Barcode demultiplexing and trimming, available directly through dorado basecaller or using dorado demux
  • Added read splitting to the simplex basecalling pipeline
  • Updated models for calling 6mA or 5mC/5hmC modified bases
  • A new 5mC/5hmC all-context model
  • More accurate 5mC/5hmC CpG-context and 6mA all-context models
  • Improvements to duplex pairing process for higher duplex yield
  • Enhancements to basecalling performance leading to higher speed and reduced memory consumption

Last updated: 2/19/2026

Latest version: 1.4.0

Approved use: For research use only

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