Long-read sequencing reveals multi-break rearrangements and aneuploidy patterns in cancer genomes
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Structural variations(SV) including insertions, deletions ,inversions, translocations and more complex events have demonstrated to contribute a large portion of population diversity as well as play a key role in a wide range of pathogenesis. Therefore comprehensive analysis of SVs is essential to decipher the genetic role players in population diversity, disease progression and tumorigenesis.