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NCM 2022: STRspy-inghidden variation in forensic DNA profiles using the MinION device


Forensic genetic analyses harness the high repeat-length variability of short tandem repeat (STR) markers for human identification. Despite the power and reliability of current typing techniques, sequence-level information within & around STRs are masked in the length-based profiles produced using capillary electrophoresis (CE). To harness the advantages of portable next generation sequencing in forensic investigations, we developed STRspy, a novel method capable of generating accurate length- & sequence-based allele designations for autosomal STRs from Oxford Nanopore reads

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