Cancer research and sequencing
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Reveal novel cancer biology. In one go.
Cancer hides in complexity. From single nucleotide variants (SNVs) to structural variants (SVs), copy number variants (CNVs), fusion transcripts, and epigenetic modifications, understanding the full picture requires looking beyond any single type of variation.
For too long, researchers have relied on multiple technologies to piece together partial answers — adding time, cost, and uncertainty. As a result, critical insights can remain hidden.
Why nanopore sequencing?
With Oxford Nanopore sequencing, you can explore the full landscape of cancer biology on a single platform, unlocking a richer view of the genome, epigenome, and transcriptome.
Any read length — from short to ultra-long (20 bp to >4 Mb)
Span even the most challenging genomic regions and capture full-length transcripts for comprehensive insights.
Multiomic data in one go
Fully explore the genome and transcriptome with built-in, gold-standard methylation detection.
Real-time results
See data as you sequence, accelerate discovery, and speed up your decision making.
Streamlined workflows
Replace multiple assays with one platform, simplify downstream analysis, and scale to your needs.
Customer spotlight
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Adaptive genome sequencing for childhood leukaemia
'We got the sample on a Tuesday morning ... and had a result by Wednesday afternoon'
Hear how Dr Thomas Alexander and global collaborators applied Adaptive Sampling — a targeted, on-device nanopore sequencing method — to over 450 childhood leukaemia cases, improving classification from 28% to up to 84% in a single assay.
End-to-end workflows
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Comprehensive human genomic variant and methylation analysis with long Oxford Nanopore reads
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Sequencing full-length transcripts for isoform-level expression analysis
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Comprehensive characterisation of cancer predisposition genes using the Hereditary Cancer Panel
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Characterising genomic and epigenomic variation between tumour-normal research samples using long nanopore sequencing reads
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Obtaining full-length isoforms from single cells with Oxford Nanopore sequencing
Featured resources
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Accelerating cancer research through comprehensive genomics
Discover how cancer researchers are using Oxford Nanopore sequencing for comprehensive characterisation of cancer samples, delivering accurate and rapid analysis of SVs, SNVs, CNVs, methylation, full-length isoforms, fusion transcripts, and splice variants — all from a single technology.
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Featured product for oncology
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Hereditary Cancer Panel
Consolidate your hereditary cancer assays and reveal more from every sample. Comprehensively characterise 258 cancer predisposition genes, including introns and promoters, and detect SNVs, indels, SVs, DNA methylation, and genome-wide CNVs in a single, streamlined workflow with less than two hours of hands-on time.
Recommended device for cancer research
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PromethION 24
Generate high-coverage whole genomes and resolve full-length transcripts with high-throughput nanopore sequencing. With up to 24 independently addressable flow cells, PromethION 24 provides the flexibility and scalability for comprehensive genomic, transcriptomic, and epigenomic analysis and biomarker discovery.
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