Professor Laurent Mesnard is Head of the Intensive Care Nephrology Unit at Assistance Publique Hopitaux de Paris Tenon Hospital, Sorbonne University, Paris, and a national coordinator for the French National plan of sequencing (PFMG2025) for rare adult kidney diseases. He co-coordinates the National Thrombotic Microangiopathies network (CNR-MAT). Prof. Mesnard’s team, located in Paris, use short-read whole-exome/genome sequencing for the clinical diagnosis of adult chronic kidney disease. They also develop applications for long-read sequencing technologies to accelerate clinical diagnosis for rare kidney diseases at their ICU admission. Another project (Allogenomics) aims to develop new metrics to evaluate the risk of chronic kidney graft failure and better allocation strategies for kidney transplantation.