Rapid and accurate pan-cancer subtyping using RNA-sequencing

Childhood cancers differ from their adult counterparts in ways not fully explained by their genomes. Exploring RNA-based methods that capture transcriptional diversity could hold the key to defining these diseases.

In this webinar, learn how Dr Adam Shlien and his team built a multi-scale transcriptomic atlas of childhood cancer that matched or clarified the diagnosis of paediatric tumours in a prospective cohort (Comitani et al., Nature Medicine, 2023). Building on this work, the team applied Nanopore direct RNA and cDNA sequencing, as part of the Sick Kids–CHU Sainte-Justine PCHP partnership, to deliver rapid tumour classification, subtyping, and fusion detection.

In this webinar:

• Learn how RNA expression can reveal clinically meaningful cancer subtypes.
• Discover real-world case studies showing direct patient impact and potential of this approach to broaden access to precision diagnostics globally.
• Recent innovations, including longer cDNA reads and multiplexed direct RNA sequencing, are making transcriptomic studies more scalable and cost-effective.