Genomic hotspots in the DENV-2 serotype (E, NS4B, and NS5 genes) are associated with dengue disease severity in the endemic region of India

Dengue fever is a global public health concern, with an estimated 390 million infections each year. Using Oxford Nanopore sequencing, researchers analysed over 3,200 DENV-2 viral genomes from India’s 2023 dengue outbreak, identifying 1.6 million single nucleotide variants (SNVs). With whole-genome analysis, they found clusters of SNVs associated with disease severity — an insight that could guide targeted interventions and inform outbreak response in the future.

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