Main menu

Characterisation of mutation patterns in non-small cell lung cancer genomes by long read whole-genome sequencing and phasing analysis


Abstract

In cancer genomes, there are various types of genomic alterations from point mutations to large structural variants. In this study, we performed long and short read whole-genome sequencing and phasing analysis of 20 non-small cell lung cancer genomes and characterized patterns of mutation occurrences in a haplotype level. We also analyzed DNA methylation and transcriptome data which were obtained by long read sequencing to reveal possible causes/consequences of genomic mutation occurrences in each haplotype. We found that complicated haplotype-biased aberrations including chromothripsis and kataegis-like events occurred in the genomes of EGFR-mutation-positive lung adenocarcinoma cases.

Biography

Ayako Suzuki is an associate professor at the University of Tokyo who graduated from Graduate School of Frontier Sciences, the University of Tokyo with a Ph.D. in 2015. She is currently working on long read sequencing of lung cancer genomes to characterize complicated mutation patterns of cancer genomes in collaboration with National Cancer Center, Japan. She is also conducting multi-layered sequencing analysis for elucidating epigenomic and transcriptomic aberrations in cancer cells.

Authors: Ayako Suzuki

入門

MinION Starter Packを購入 ナノポア製品の販売 シークエンスサービスプロバイダー グローバルディストリビューター

ナノポア技術

ナノポアの最新ニュースを購読 リソースと発表文献 Nanopore Communityとは

Oxford Nanoporeについて

ニュース 会社沿革 持続可能性 経営陣 メディアリソース & お問い合わせ先 投資家向け パートナー向け Oxford Nanopore社で働く 現在の募集状況 営業上の情報 BSI 27001 accreditationBSI 90001 accreditationBSI mark of trust
Japanese flag