Main menu

NCM 2022: The distribution and genetic variations of Epstein–Barr virus in sub-Saharan Africa


Epstein–Barr virus (EBV) infects most of the world’s population and underlies around 1% of all cancers, including endemic Burkitt lymphoma (eBL), a prevalent pediatric cancer in sub-Saharan Africa. Its natural history and role of viral variation are not well understood. Thus, EBV types and genetic variants were explored in the saliva of healthy Kenyans compared with isolates from individuals with eBL. Long-read nanopore sequencing of key genes central to transformation was performed for a complete description of complex insertions and deletions within the repeat regions. Within the population, we observed more EBV type 1 (70.7%) than type 2 (29.3%). Type 1 had a greater average number of LMP1 (p<0.008) and EBNA3C variants (p<0.02), and two intertypic genomes were identified. Future studies may harness this sensitive, robust method to study viral variations on more eBL and healthy individuals and other EBV-associated cancers in Africa.

Authors: Sin Ting (Abbie) Hui

入门指南

购买 MinION 启动包 Nanopore 商城 测序服务提供商 全球代理商

纳米孔技术

订阅 Nanopore 更新 资源库及发表刊物 什么是 Nanopore 社区

关于 Oxford Nanopore

新闻 公司历程 可持续发展 领导团队 媒体资源和联系方式 投资者 合作者 在 Oxford Nanopore 工作 职位空缺 商业信息 BSI 27001 accreditationBSI 90001 accreditationBSI mark of trust
Chinese flag