Accurate Accelerated Read Clustering in The Nanopore Signal Domain
- Published on: May 19 2023
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While basecalling is widely researched and utilized today in many DNAanalysis pipelines, itis both computationally expensive and possessesan inherent loss of information since it converts real-valued signalsinto discrete bases. In this work, we propose a novel approach tha exploits the additional information available in the raw signals toboth improve alignment accuracy and accelerate DNA analysis infields such as Chemistry, Biology, Medicine, and DNA storage.
