Nanopore sequencing identifies transcriptomic structural variation in mouse colorectal cancer T-cell immune checkpoints: a comparison of short read (Illumina) and long read (Nanopore) sequencing technologies
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Tumour infiltrating lymphocytes (TILs) become progressively less effective in responding to cancer. This process, called T cell exhaustion, is characterised by a temporally hierarchical loss of effect or functions with increased expression of inhibitory immune checkpoints, culminating in terminally differentiated but ineffective Tcell populations.