LAST
- shared.published_on: April 20 2015
- shared.source: LAST: Genome-Scale Sequence Comparison
Martin Frith, Computational Biology Research Center in Tokyo
Release Date: 18-Sep-2015
LAST finds similar regions between sequences, and aligns them. It is designed for comparing large datasets to each other (e.g. vertebrate genomes and/or large numbers of DNA reads). It can:
- Indicate the (un)ambiguity of each column in an alignment
- Use sequence quality data in a rigorous fashion
- Align DNA to proteins with frameshifts
- Compare PSSMs to sequences
- Calculate the likelihood of chance similarities between random sequences
- Do split and spliced alignment
