Analysing the impact of sexual recombination on the segregation of virulence genes in African trypanosomes
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Trypanosomes are responsible for both Human and Animal African trypanosomiasis, causing severe health and economic burdens across sub-Saharan Africa. The lifecycle of trypanosomes is shown in Figure 1. Trypanosomes are extracellular parasites – they frequently change expression of their variant surface glycoproteins (VSGs), encoded at their telomeres, which cover the surface of bloodstream parasites to evade host immune responses [1-2] (Figure 2).