The 15th International Workshop on Advanced Genomics
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The development of genome analysis technologies is accelerating year by year. Advances in long-read DNA sequencing technologies, such as nanopore sequencing, and single-cell resolution multi-omics data collection are progressing rapidly. Consequently, there is an increasing need for establishing robust analysis infrastructure to handle the vast amounts of data, along with the enhancement of analysis technologies that include artificial intelligence (AI). These technological advancements are driving data-driven discoveries in the life sciences, expanding the possibilities for further applications. There are also high expectations for the acceleration of genomic science research through international collaboration.
In response to the rapid developments in the field of genomic medicine, the 15th International Genome Conference will be held. This conference aims to explore the latest achievements and new developments brought about by cutting-edge technologies under the theme "Genome, Cell and Disease."
The conference will take place over three days from July 2 to July 4, 2025, at Hitotsubashi Hall (National Center of Sciences). Oxford Nanopore will be the Silver sponsor for this conference. Stop by at booth number 11, or join us for the Oxford Nanopore Luncheon Seminar.
Time: Wednesday 2 July 2025
Venue: Hitotsubashi Hall (National Center of Sciences)
Speakers
Cancer genomes harbor various aberrations in genomic and epigenomic layers. Long-read whole-genome sequencing (WGS) enables revealing precise structures of complicated genomic aberrations in cancer genomes. Further, a long-read sequencer PromethION simultaneously elucidates patterns of DNA methylation in addition to DNA sequences. In this presentation, we introduce the results of WGS analysis for large-cell neuroendocrine carcinoma (LCNEC) which is a very aggressive type of lung cancers. We analyzed 21 LCNEC genomes using PromethION. We detected diverse types of genomic rearrangements, such as simple structural variants, long insertions, chromothripsis and extrachromosomal DNAs. At the epigenomic layer, most of the LCNEC genomes showed genome-wide DNA hypomethylation compared with normal tissue genomes. By comprehensively identifying the complicated genomic and epigenomic features in LCNECs, we would precisely understand molecular features that might be associated with tumor aggressiveness and therapeutic difficulties.
Cancer genomes harbor various aberrations in genomic and epigenomic layers. Long-read whole-genome sequencing (WGS) enables revealing precise structures of complicated genomic aberrations in cancer genomes. Further, a long-read sequencer PromethION simultaneously elucidates patterns of DNA methylation in addition to DNA sequences. In this presentation, we introduce the results of WGS analysis for large-cell neuroendocrine carcinoma (LCNEC) which is a very aggressive type of lung cancers. We analyzed 21 LCNEC genomes using PromethION. We detected diverse types of genomic rearrangements, such as simple structural variants, long insertions, chromothripsis and extrachromosomal DNAs. At the epigenomic layer, most of the LCNEC genomes showed genome-wide DNA hypomethylation compared with normal tissue genomes. By comprehensively identifying the complicated genomic and epigenomic features in LCNECs, we would precisely understand molecular features that might be associated with tumor aggressiveness and therapeutic difficulties.
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Ayako Suzuki, Graduate School of Frontier Sciences, The University of TokyoIn this Luncheon seminar, we will present the latest update announced at London Calling 2025. Oxford Nanopore Technologies (ONT) continues to advance its technologies under the "Complete Biology" initiative, aiming to enable comprehensive analysis across genomes, epigenomes, transcriptomes, and proteomes. With the latest improvements in Dorado basecalling, higher accuracy has been achieved, enhancing capabilities in DNA and RNA modification detection, targeted sequencing, and support for telomere-to-telomere (T2T) assembly. Furthermore, ONT has embarked on a new challenge in protein analysis, expanding the possibilities for multi-omics research. These advances support the development of more streamlined and integrated multi-omic workflows, and lay the groundwork for more comprehensive, real-time analysis of complex biological systems.
In this Luncheon seminar, we will present the latest update announced at London Calling 2025. Oxford Nanopore Technologies (ONT) continues to advance its technologies under the "Complete Biology" initiative, aiming to enable comprehensive analysis across genomes, epigenomes, transcriptomes, and proteomes. With the latest improvements in Dorado basecalling, higher accuracy has been achieved, enhancing capabilities in DNA and RNA modification detection, targeted sequencing, and support for telomere-to-telomere (T2T) assembly. Furthermore, ONT has embarked on a new challenge in protein analysis, expanding the possibilities for multi-omics research. These advances support the development of more streamlined and integrated multi-omic workflows, and lay the groundwork for more comprehensive, real-time analysis of complex biological systems.
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Jihye Kim, Senior Field Applications Scientist, Oxford Nanopore Technologies
