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Dorado basecall server
High-performance commandline basecaller in a client-server configuration as used in MinKNOW. Documentation is included in the package README.md.
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Version: 7.11.2
Release date: 10/30/2025
Approved use: For research use only
Dorado upgrade
- Now integrates Dorado v1.1.1
Update to v5.2.0 DNA basecalling models
- Increased HAC basecalling and modification calling accuracy
- Faster all-context modification calling
- Support for 6mA-tagged chromatin accessibility data
- Performance enhancements across platforms
Support changes
- Distributed builds of Dorado Basecall Server 7.11.2 are now created on Rocky Linux 8 to support Linux systems using glibc 2.28 or above. CentOS 7 is no longer supported.
- The last major Mk1C release was 7.9.8 and no further releases are planned.
- Added support for SQK-DRB004-24 RNA barcoding kit.
- Removed support for DNA R9.4.1 models.
- Removed support for RNA002 models.
- Removed support for reading FAST5 files.
Output changes
- Additional poly(A) tail estimation metrics
- Sequencing summary and other updates to comply with the Oxford Nanopore Output Specifications documentation
Other improvements
- Poly(A) tail estimation improvements with interrupted tails in plasmids
- Support for split indexes when aligning
- Dynamic resource management using Slurm
- Security updates
- Bug fixes
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