Resolving vector insertion sites and cell line characterization with long-read sequencing: insights from PRINT
)
- Published on:
In this on-demand webinar, hear Kyle Burbach (Addition Therapeutics) present data from platform development and pre-clinical work using PRINT, a site-specific transgene integration platform. The talk highlights the use of Oxford Nanopore long-read sequencing to investigate insertion specificity in primary human hepatocytes, characterize rDNA methylation, assess transgene integrity, and apply sensitive alignment strategies for accurate detection of integration events.
You'll also get an overview of nanopore sequencing, and see how Oxford Nanopore platforms can support vector insertion site analysis using approaches such as whole-genome sequencing and adaptive sampling.
