Cell-specific RNA isoform remodelling in the ageing mouse brain


Using Oxford Nanopore sequencing, Rehman et al. built a full-length RNA isoform atlas in two regions of the mouse brain, revealing thousands of cell-type and age-related transcript changes. This enabled unprecedented insights into ageing biology and neurodegeneration, offering a path to earlier detection and intervention for age-linked brain disorders in the future.

Sample type: mouse brain

Kit: cDNA-PCR Sequencing Kit

Authors: Abid Rehman, Megan Duffy, Katarina Gresova, Cedric Belair, Na Yang, Lin Wang, Christopher T. Lee, Matthew Payea, Sulochan Malla, Showkat Ahmad Dar, Payel Sen, Mark R. Cookson, Manolis Maragkakis