Cell-specific RNA isoform remodelling in the ageing mouse brain
Using Oxford Nanopore sequencing, Rehman et al. built a full-length RNA isoform atlas in two regions of the mouse brain, revealing thousands of cell-type and age-related transcript changes. This enabled unprecedented insights into ageing biology and neurodegeneration, offering a path to earlier detection and intervention for age-linked brain disorders in the future.
Sample type: mouse brain