Translocation and extrachromosomal DNA (ecDNA) detection in cancer using low-pass Pore-C sequencing

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Pore-C cancer poster

Chromatin conformation capture detects the presence of translocations and ecDNA at low sequencing depth and without the need for breakpoint-spanning reads.

Download the poster to discover:

  • More about translocations and extrachromosomal DNA in cancer
  • How native Pore-C libraries from cancer cells or tissue can be prepared and analysed
  • The unique signatures in Pore-C contact matrices produced by translocations and ecDNA
  • About how detected chromosomal anomalies can be validated with nanopore adaptive sampling
Download the PDF