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Significant and pervasive effects of RNA degradation on nanopore direct RNA sequencing


Oxford Nanopore’s direct RNA sequencing (DRS) is a powerful tool capable of sequencing native RNA molecules.

DRS has many advantages:

  • Designed to sequence complete or full-length molecules.
  • Accurately measures both gene and isoform expression levels.
  • DRS sequences native RNA molecules meaning no need for RT-PCR

The precision and reliability of DRS can be heavily dependent upon RNA integrity (RIN is a measure of RNA integrity and ranges from 1-10).

Often RNA from in vivo or clinical samples have undergone some degradation.

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