Pharmacogenomics (PGx)
We conclude that PGx based on targeted [long-read sequencing] is a valuable tool to advance the implementation of personalised medicine
Deserranno, K. et al. Front. Pharmacol. (2023)
Access full-gene, long-read coverage results to unambiguously phase haplotypes for PGx star allele and variant calling
Call all PGx variants, including small and structural variants, and complex copy number alterations
Achieve high-confidence, comprehensive PGx sequencing at your choice of throughput
Comprehensively characterise PGx gene variants in a single assay
Pharmacogenomics (PGx) is the study of how genomics influences drug responses with the aim of identifying precise drug treatments for individuals. Genomic variation influences how drugs are absorbed, distributed, and metabolised (pharmacokinetics), as well as how they interact with biological pathways (pharmacodynamics). Furthermore, genetic differences can contribute to adverse drug reactions, such as hypersensitivity and allergic reactions, highlighting the need for personalised drug dosing based on genetics to improve treatment outcomes.
A major challenge of PGx is the complexity and diversity of genomic variations, which cannot be characterised on one platform using traditional methods. Oxford Nanopore Technologies offers a complete PGx solution, enabling comprehensive analysis all PGx variations in a single assay.
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Oxford Nanopore sequencing of PGx loci for calling variants
Find the highlighted publications that demonstrate how researchers are taking advantage of nanopore technology to study pharmacogenomics.
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Nanopore sequencing of the Twist Alliance Long-Read PGx Panel
Discover how the Oxford Nanopore and Twist Bioscience research workflow enables comprehensive characterisation of PGx targets.
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The GridION is a compact benchtop device, designed to run and analyse up to five MinION Flow Cells. Run multiple experiments sequentially with the independently addressable flow cells and onboard compute — ideal for high-throughput sequencing of PGx genes.
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Flexible, affordable, high-output nanopore devices for every lab — in a compact, accessible form.
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A flexible, large-scale, direct DNA and RNA sequencing device — delivering on-demand access to terabases of data.
