Real-time genomics for rapid clinical pathogen identification and resistance prediction in bloodstream infections

Why focus on gram-negative bacteria?

• Gram-negatives as WHO pathogens of concern due to their growing resistance rates

• Natural inhabitants of the GI-tract of humans and animals

- High exposure to antibiotics

- High potential for transmission

In particular, Klebsiella pneumoniae harbours an abundance of resistance and virulence genes

Why use real-time genomics for bloodstream infections?

• Genomic information to understand evolution and transmission

• Metagenomics to assess the entirety of microorganisms in the bloodstream

• Rapid identification of resistance and virulence patterns

• Reduction of turnover time

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