NCM 2022: Update from Oxford Nanopore Technologies

At the Nanopore Community Meeting, Rosemary Sinclair Dokos, Stuart Reid and Lakmal Jayasinghe showed how the Oxford Nanopore sequencing platform’s capabilities continue to be pushed. They provided a summary of the current platform, imminent platform developments, and the innovation pipeline. Multiple updates and consolidations to improve and simplify the platform were presented, showcasing a single, simple, high-performance sequencing technology.

The latest R10.4.1 flow cells in combination with Kit 14, for high-yield, high-accuracy (Q20+ single molecule) sequencing, are expected to move from ‘early access’ to ‘released’ status in the first quarter of 2023. This enables all users to generate highly accurate, information-rich data, in real time and from any length fragments of DNA/RNA, providing one platform for all users’ sequencing needs.

Updates were provided that included developments in platform chemistry, hardware, data analysis, preparation and product range:

Current platform status and imminent developments

• Comprehensive, information-rich genomics

• Low cost, high-yield accessible sequencing

• Simple, versatile and consistent platform for end-to-end analysis

• Simple pathways for assay developers: Project TurBOT and Q-Line

• Unique platform features

Pipeline developments: Towards sequencing by anyone, anywhere