Main menu

Navigating cell and gene therapy: the benefits of whole-genome profiling


Cell and gene therapy research often requires inserting large, multi-kilobase DNA sequences into the genome. These knock-in experiments enable scientists to investigate gene function and develop new treatments. However, rigorous validation is required to confirm insertion accuracy and detect unintended genomic changes, which remain challenging.

In this webinar, Monica Sentmanat presented long-read sequencing of captured multi-kilobase targets (LOCK-seq). This advanced whole-genome profiling approach precisely confirms multi-kilobase knock-ins and detects genome-wide changes, ensuring reliable research models and enhancing the safety of innovative therapies.

Watch this webinar to learn:

  • How to achieve high on-target coverage in knock-in verification.

  • Strategies for cost-effective LOCK-seq multiplexing and data analysis.

  • The benefits of nanopore sequencing for cell and gene therapy research.

Authors: Monica Sentmanat, Genome Engineering and Stem Cell Center at the McDonnell Genome Institute

入门指南

购买 MinION 启动包 Nanopore 商城 测序服务提供商 全球代理商

纳米孔技术

订阅 Nanopore 更新 资源库及发表刊物 什么是 Nanopore 社区

关于 Oxford Nanopore

新闻 公司历程 可持续发展 领导团队 媒体资源和联系方式 投资者 合作者 在 Oxford Nanopore 工作 职位空缺 商业信息 BSI 27001 accreditationBSI 90001 accreditationBSI mark of trust
Chinese flag