Native telomere sequencing of individual chromosomes using 3’ end adapter ligation with Telo-seq
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Direct adapter ligation to chromosome ends enables precise telomere mapping, length characterization, and phasing to determine telomere maintenance mechanisms in cancer and telomere shortening with human age.
Download the poster to discover:
- How nanopore adapters are ligated to the ends of telomeres via splint ligation
- That telo-seq barcoding enables multiplexed telomere length and chromosome mapping
- How telo-seq resolves cancer maintenance pathways and age-related shortening
- More about haplotype-resolved telomere mapping and how it reveals heterogeneity among chromosomes
